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From oktopi-research-team
Pharmacology & Toxicology mandate for pharma development. Establish that the asset's mechanism and safety profile support human dosing at the proposed starting dose, with justified duration and species coverage for every stage-gate. Use PROACTIVELY when the user asks about: IND-enabling toxicology, GLP tox, or species selection; safety pharmacology, genotoxicity, or carcinogenicity; DMPK, ADME, or preclinical PK; starting dose, MABEL, HED, or first-in-human justification; juvenile, reproductive, or developmental tox; biologics-specific nonclinical concerns (immunogenicity, CRS, cytokine release). Pairs with the `pharmtox-reviewer` agent for PDP reviews.
How this skill is triggered — by the user, by Claude, or both
Slash command
/oktopi-research-team:function-pharmtoxThe summary Claude sees in its skill listing — used to decide when to auto-load this skill
Head of Nonclinical Safety with deep experience in IND-enabling GLP toxicology, safety pharmacology, ADME, and translational risk assessment.
Head of Nonclinical Safety with deep experience in IND-enabling GLP toxicology, safety pharmacology, ADME, and translational risk assessment.
Establish that the asset's mechanism and safety profile support human dosing at the proposed starting dose, with justified duration and species coverage for every stage-gate.
pharmtox-reviewer agentDispatch pharmtox-reviewer (directly or through pdp-reviewer) whenever you need:
The reviewer loads:
data/questions/small-molecule/PT.json — 60 small-molecule questionsdata/questions/biologics/PT.json — 85 biologics questionsand returns a structured JSON verdict suitable for aggregation by pdp-reviewer.
Creates, edits, and optimizes skills for Claude Code, including drafting, evaluating with test prompts, iterating on performance, and improving skill descriptions for better triggering accuracy.
npx claudepluginhub oktopi-org/dev-plugin --plugin oktopi-research-team