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From clawbio
Simulates meiotic recombination to produce offspring genomes from parent pairs, modeling Mendelian segregation, mutation, and clinical evaluation.
How this skill is triggered — by the user, by Claude, or both
Slash command
/clawbio:recombinatorThe summary Claude sees in its skill listing — used to decide when to auto-load this skill
Produce offspring genomes from selected parent pairs via simulated meiotic
Produce offspring genomes from selected parent pairs via simulated meiotic recombination. Models Mendelian segregation, de novo mutation, sex determination, and clinical evaluation against a disease registry.
.genome.json files (one Male, one Female)GENOMEBOOK/DATA/trait_registry.jsonGENOMEBOOK/DATA/disease_registry.json.genome.json with:
# Demo: breed Einstein x Anning, produce 3 offspring
python skills/recombinator/recombinator.py --demo
# Breed specific parents
python skills/recombinator/recombinator.py \
--father einstein-g0 --mother anning-g0 --offspring 3
# Custom generation number
python skills/recombinator/recombinator.py \
--father einstein-g0 --mother curie-g0 --offspring 2 --generation 1
ID: g1-001-a3f2c1
Sex: Female (XX)
Health: 0.9500
Mutations: 1
- COMT_Val158Met: G->A (neutral, from mother)
Conditions: 0
Top traits:
- curiosity: 0.92
- analytical_thinking: 0.88
- persistence: 0.85
npx claudepluginhub clawbio/clawbio --plugin clawbioScores genetic compatibility across all male-female pairings in a Genomebook generation using heterozygosity, trait complementarity, and disease risk. Outputs ranked pairings and selected mating pairs.
Looks up allele frequencies from gnomAD and 1000 Genomes, runs HWE/Fst/inbreeding tests, queries GWAS associations and ClinVar, and computes evolutionary constraint scores. Best for cross-population variant comparison.
Queries the Monarch Initiative knowledge graph for disease-gene-phenotype associations across species, integrating OMIM, ORPHANET, HPO, ClinVar, and model organism databases. Use for rare disease gene discovery, phenotype mapping, and cross-species modeling.